Study towards equipment for isolation and combined drying and wetting (internship)

At Aspen in Oss, we contribute to the health and well-being of people all over the world. We make active pharmaceutical ingredients, the active ingredients in a medicine. Our APIs are of high quality and are used worldwide. We are committed to always offering the optimal solution for our customers. Improving our processes and ourselves is therefore really in our DNA. We think from top to bottom in solutions to issues and work together on new products. We show respect for society and the environment in everything we do.


Internship chemical engineering

Problem description

Rocuronium bromide is produced in building BB. The last process step consists of a precipitation, isolation of the crystals, followed by a sequence of drying-wetting-drying. The wetting and drying process takes approximately 5 days. During that time, the filter dryer cannot be used for the next process. Especially, as we are aiming to reduce the throughput time of the preceding processes, the filter dryer is the bottle-neck in production speed improvement.

If this wetting-drying sequence can be done in a separate unit, this will substantially decrease the total process time in the fixed equipment.


Design a solution to perform the isolation, drying and wetting of Rocuronium bromide in considerably less time and not hampering production flow of the preceding processes.

The solution may be in optimizing the current use of the filter dryer, or the use of a completely different type of equipment such as fluid bed or flash dryer. The solution must fit in our goals to improve sustainability.


For more information about the content of the position please contact Marcia van Loo, E: